{"id":1530,"date":"2024-12-03T00:26:05","date_gmt":"2024-12-03T03:26:05","guid":{"rendered":"https:\/\/cormanich.iqm.unicamp.br\/?p=1530"},"modified":"2024-12-03T00:26:05","modified_gmt":"2024-12-03T03:26:05","slug":"new-paper-in-joc","status":"publish","type":"post","link":"https:\/\/cormanich.iqm.unicamp.br\/?p=1530","title":{"rendered":"New paper in JOC"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">We\u2019re excited to present our latest findings on the <strong>ring-opening reaction of fluorinated oxetanes by halides<\/strong>. This highly stereoselective reaction, directed by the presence of a fluorine atom, enabled the preparation of <strong>tetrasubstituted alkenes<\/strong> and <strong>pyrrolidines<\/strong> with all-carbon quaternary centers\u2014valuable compounds in synthetic chemistry.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On the computational side, <strong>transition state calculations<\/strong> illuminated the regioselectivity of the reaction. These studies, benchmarked with high-level methods. Using <strong>NBO analysis<\/strong>, we uncovered that a destabilizing <strong>F\u03b4\u2212\u00b7\u00b7\u00b7Br\u207b electrostatic interaction<\/strong> is a key factor shaping the reaction outcome.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This work underscores the synergy between experimental and theoretical approaches in advancing modern organic synthesis. Thanks a lot the Lequeux lab for all the collaborative work;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We\u2019re excited to present our latest findings on the ring-opening reaction of fluorinated oxetanes by halides. This highly stereoselective reaction, directed by the presence of a fluorine atom, enabled the preparation of tetrasubstituted alkenes and pyrrolidines with all-carbon quaternary centers\u2014valuable compounds in synthetic chemistry. On the computational side, transition state calculations illuminated the regioselectivity of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1531,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-1530","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-post"],"_links":{"self":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1530"}],"version-history":[{"count":1,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1530\/revisions"}],"predecessor-version":[{"id":1532,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1530\/revisions\/1532"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/media\/1531"}],"wp:attachment":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}