{"id":1603,"date":"2025-05-14T15:20:46","date_gmt":"2025-05-14T18:20:46","guid":{"rendered":"https:\/\/cormanich.iqm.unicamp.br\/?p=1603"},"modified":"2025-05-14T15:24:22","modified_gmt":"2025-05-14T18:24:22","slug":"new-colaborative-paper-in-chemistry-an-asian-journal","status":"publish","type":"post","link":"https:\/\/cormanich.iqm.unicamp.br\/?p=1603","title":{"rendered":"New colaborative paper in Chemistry &#8211; An Asian Journal"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"745\" height=\"316\" src=\"https:\/\/cormanich.iqm.unicamp.br\/wp-content\/uploads\/image.png\" alt=\"\" class=\"wp-image-1604\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Excited to share our latest collaborative work with the <strong>Jurberg group<\/strong>:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>&#8220;Visible Light-Mediated Preparation of a Key Intermediate Employed in the Synthesis of Zolpidem and Several Analogs&#8221;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this study, we developed a <strong>visible light-driven C3-alkylation protocol<\/strong> for imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines using <strong>aryldiazoacetates<\/strong>. This strategy provides efficient access to known and novel analogs of a key intermediate used in the synthesis of <strong>zolpidem<\/strong>. A formal synthesis of this key intermediate was also achieved, requiring fine-tuning of the alkylating agent\u2019s structure.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our group contributed with theoretical calculations to help unravel the reactivity and mechanistic pathway of the transformations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udcc4 Check out the full article here: <a href=\"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202500455\">https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202500455<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Excited to share our latest collaborative work with the Jurberg group: &#8220;Visible Light-Mediated Preparation of a Key Intermediate Employed in the Synthesis of Zolpidem and Several Analogs&#8221; In this study, we developed a visible light-driven C3-alkylation protocol for imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines using aryldiazoacetates. This strategy provides efficient access to known and novel analogs of a&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-1603","post","type-post","status-publish","format-standard","hentry","category-post"],"_links":{"self":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1603"}],"version-history":[{"count":2,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1603\/revisions"}],"predecessor-version":[{"id":1607,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1603\/revisions\/1607"}],"wp:attachment":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}