{"id":1693,"date":"2026-09-01T17:51:02","date_gmt":"2026-09-01T20:51:02","guid":{"rendered":"https:\/\/cormanich.iqm.unicamp.br\/?p=1693"},"modified":"2026-09-01T17:51:02","modified_gmt":"2026-09-01T20:51:02","slug":"new-publication-in-chemical-science","status":"publish","type":"post","link":"https:\/\/cormanich.iqm.unicamp.br\/?p=1693","title":{"rendered":"New publication in Chemical Science"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Our group has recently published a new study in <em>Chemical Science<\/em> (2026) in collaboration with <strong>Prof. David O\u2019Hagan<\/strong>, from the University of St Andrews.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The work explores the incorporation of the <strong>tris-fluoromethylated motif (\u2013CF\u2082H)\u2083C\u2013<\/strong> into heterocycles, amino acids, and analogues of the high-profile pharmaceuticals <strong>elexacaftor and tezacaftor<\/strong>, investigating how this fluorinated motif influences molecular polarity, acidity, lipophilicity, and steric properties.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This collaboration highlights the potential of fluorine chemistry in the design and optimisation of bioactive molecules.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Stewart, J. M.; Piscelli, B. A.; Cordes, D. B.; Cormanich, R. A.; O\u2019Hagan, D.<\/strong> <em>Chem. Sci.<\/em> <strong>2026<\/strong>, <em>17<\/em>, 15938\u201315946.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our group has recently published a new study in Chemical Science (2026) in collaboration with Prof. David O\u2019Hagan, from the University of St Andrews. The work explores the incorporation of the tris-fluoromethylated motif (\u2013CF\u2082H)\u2083C\u2013 into heterocycles, amino acids, and analogues of the high-profile pharmaceuticals elexacaftor and tezacaftor, investigating how this fluorinated motif influences molecular polarity,&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1694,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-1693","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-post"],"_links":{"self":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1693"}],"version-history":[{"count":1,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1693\/revisions"}],"predecessor-version":[{"id":1695,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/posts\/1693\/revisions\/1695"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=\/wp\/v2\/media\/1694"}],"wp:attachment":[{"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cormanich.iqm.unicamp.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}