Excited to share our latest collaborative work with the Jurberg group:
“Visible Light-Mediated Preparation of a Key Intermediate Employed in the Synthesis of Zolpidem and Several Analogs”
In this study, we developed a visible light-driven C3-alkylation protocol for imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines using aryldiazoacetates. This strategy provides efficient access to known and novel analogs of a key intermediate used in the synthesis of zolpidem. A formal synthesis of this key intermediate was also achieved, requiring fine-tuning of the alkylating agent’s structure.
Our group contributed with theoretical calculations to help unravel the reactivity and mechanistic pathway of the transformations.
📄 Check out the full article here: https://aces.onlinelibrary.wiley.com/doi/10.1002/asia.202500455
