We are thrilled to announce the publication of our latest research paper in Chemical Communications, the result of a fruitful collaboration with Professor Igor Jurberg. The study presents a groundbreaking reaction sequence that combines visible light-mediated cyclopropanation with acid-promoted ring-opening, leading to the formal alkylation of silyl enol ethers with aryldiazoacetates.
In this work, we explore a unique reaction between Danishefsky’s diene and aryldiazoacetates, which undergoes a [4+1]-cycloaddition to generate novel adducts under the same reaction conditions. Our paper delves into the key mechanistic aspects of these transformations, providing detailed insights through both experimental data and Density Functional Theory (DFT) calculations.
Check out the full article in Chemical Communications for more details on our findings: https://doi.org/10.1039/D4CC05451B
